|Title||A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||B Button, L-H Cai, C Ehre, M Kesimer, DB Hill, JK Sheehan, RC Boucher, and M Rubinstein|
|Journal||Science China. Life Sciences|
|Pagination||937 - 941|
Mucus clearance is the primary defense mechanism that protects airways from inhaled infectious and toxic agents. In the current gel-on-liquid mucus clearance model, a mucus gel is propelled on top of a " watery " periciliary layer surrounding the cilia. However, this model fails to explain the formation of a distinct mucus layer in health or why mucus clearance fails in disease. We propose a gel-on-brush model in which the periciliary layer is occupied by membrane-spanning mucins and mucopolysaccharides densely tethered to the airway surface. This brush prevents mucus penetration into the periciliary space and causes mucus to form a distinct layer. The relative osmotic moduli of the mucus and periciliary brush layers explain both the stability of mucus clearance in health and its failure in airway disease.
|Short Title||Science China. Life Sciences|